Welcome to the final CryoCloud newsletter of 2025!
Between new algorithms, major product launches, our €2M funding round, a doubled team, and the CryoCloud platform's 3-year anniversary, 2025 has been our biggest year yet.
Thank you for being part of this journey, whether you’ve processed thousands of movies with us this year, joined a webinar, shared feedback, or simply followed along.
Here’s what’s inside:
▸ 2025 Year in Review: highlights & milestones
▸ CryoCloud Platform Turns 3!
▸ Science Spotlight: small molecule case studies ▸ New algorithms & platform additions ▸ Free trial & academic access ▸ Upcoming events calendar
🎉 2025 Year in Review
2025 was a transformative year for CryoCloud — packed with technical progress, product launches, and community growth. Here are the moments that shaped this year:
Five new algorithms were developed in-house and added to the app: automated shape mask creation for improved results and automation (AutoMask), reference-based 3D & 2D class selection (AutoClass3D & AutoClass2D), GPU-accelerated MotionCorrection (MotionCorr CC), and micrograph contamination detection and removal (part of CryoCloud Picker).
New tools to enable end-to-end automated workflows.
Introduction of Targets and a series of project-grid improvements to make data management faster and more intuitive.
🔬 Large-scale EMPIAR benchmarks and case studies
We validated CryoCloud automated workflows at scale — from an 8-dataset GPCR benchmark to a 53-dataset EMPIAR study spanning five distinct target classes. Additional case studies across small molecule drug discovery, antibody discovery and vaccine design further demonstrated consistent, interpretable results across targets ranging from ~85 kDa to large, heterogeneous complexes.
🌍 Growing adoption across industry & academia
We welcomed new private-cloud deployments, new evaluation customers, and a steadily growing academic user base — now spanning 25+ countries.
👥 Team expansion & organisational growth
We doubled in size this year (growing from 6 to 12 people!), strengthening our scientific, engineering, product, applications, and commercial teams. This expansion allows us to build faster, support more users, and push automation further across the platform.
📣 Funding to accelerate innovation
We announced a €2M seed round, supporting faster development and deeper automation across our workflows.
And of course…
🎂 CryoCloud Platform Turns 3
December 5th marked three years since CryoCloud went live. Here’s what three years look like in numbers:
🌍 Used by researchers in 25+ countries 💻 100,000+ GPU hours processed 🔬 Thousands of datasets analysed across cryo-EM & X-ray crystallography 🚀 355 production deploys + 2,158 staging deploys 👥 A global and fast-growing user community 🧠 Five new algorithms shipped ⚡ Fully automated workflows built across the entire platform 🔐 ISO 27001-certified processes & infrastructure
But the numbers only tell part of the story — the real milestone is the growing CryoCloud community 💙
Here’s to the next 3 years!
🔬 Science Spotlight
Our recent Map of the Month series featured two small molecule case studies reprocessed on CryoCloud:
📌 October – GLP-1 receptor in complex with its natural ligand GLP-1
Final map: 2.7 Å from 40 hours of cloud computing
📌 November – CDK-activating kinase bound to the covalent inhibitor THZ1
Final map: 2.5 Å from 52 hours of cloud computing
Curious to know more about these case studies, or what CryoCloud could do with your own data?You can try the platform yourself, or we can run a benchmark on your dataset to show what’s possible.
📅 Book a call with us using the button below – we’d love to chat!
End-to-end automated workflow for macromolecular crystallography
CryoCloud Picker improvements: New GPCR-specific model and contamination segmentation for more robust particle picking across challenging datasets.
Automation enablers: Automated uploads, automated masking, and reference-based 2D & 3D class selection to reduce manual intervention and improve consistency.
Helical reconstruction workflow: End-to-end data processing from raw movies to final maps for helical specimens.
New tools, including LocScale2, CryoSieve, EMReady and many platform improvements for data management and ease of use.
Want the full details? We now publish public release notes for every CryoCloud version, covering new features, improvements, and fixes.
As we close out 2025, we want to thank every user and collaborator who contributed to CryoCloud’s growth this year. Your trust, questions, feature requests, datasets, and feedback make CryoCloud better every single week.
From all of us at CryoCloud — wishing you a warm, restful holiday season and an inspiring start to 2026.
